- "Downtown City. Home to two million people. Make that two million and two."
- —Blythe, Blythe's Big Adventure Part One
Downtown City is the main setting in the Littlest Pet Shop series and home to most characters. Blythe lived in her hometown until her father got a promotion in Blythe's Big Adventure Part One, which made them have to move into the city. Its layout seems to resemble that of New York City, specifically Manhattan Island.
- 72 Oak Street - Inhabitants: Blythe Baxter, Roger Baxter, and Sunil and Vinnie's owners.
- Biskit Mansion - Inhabitants: Brittany and Whittany Biskit, Fisher Biskit, Eliza Biskit, and François LeGrande
- Alice's apartment building - Inhabitants: Alice and her mother.
- Sunset Siesta Retirement Village
- Littlest Pet Shop
- Largest Ever Pet Shop
- Sweet Delights
- One Last Chance Thrift Shop
- Diamond Hills
- East Side
- Coffee Shop Block